To give you an idea of how a screen reader functions, WebAIM (Web Accessibility in Mind) has produced a simulation with three tasks to complete using screen-reader-like functionality.
The example they use is made up (the University of the Antarctic), but it should give you at least a small “look” into what it is like to navigate the Web via a screen reader.
They also have a cognitive disability simulation, and a low vision simulation.
And to actually try one, pick a screen reader from W3C's list of alternative browsers:
http://www.w3.org/WAI/References/Browsing
Thanks for the link! I have been thinking a lot about design as it pertains to people w/ disabilities and this is a great resource.
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