The archives at the Cathedral Church Of Saint Peter In Exeter have some interesting examples of layouts from centuries ago.

Rosa Medicinae
“A page from John de Gaddesden’s Rosa Medicinae, a 14th century work. The author is mentioned in the Prologue to Chaucer’s ‘Canterbury Tales’. This is almost certainly the earliest medical work surviving in Exeter.”

Pythagoras’ Theorem
“Proof of the Theorem of Pythagoras in Euclid’s De Arte Geometrica – late 13th century.”

Milton’s Tenure of Kings and Magistrates
“Frontispiece of John Milton’s ‘The Tenure of Kings and Magistrates’ 1649, with a presentation inscription ‘from the author’.”